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Prof. Anne-Marie ROUSSEL

醫生 安娜瑪麗?羅素教授


頭銜 法國格勒諾布爾-阿爾卑斯大學生化系終身教授
領域 生化學

? Pharmacien, Docteur en Pharmacie, Docteur e?s Sciences
? Professeur E?me?rite des Universite?s
? Discipline Biochimie Ge?ne?rale, Me?tabolique et Nutritionnelle Universite? Grenoble Alpes

課程：臨床生理營養和功能醫學
內容

課程內容

生理營養和功能醫學，包括臨床研究、生理學、生物學研究以及宏觀和微量營養素不平衡的管理，同時考慮到它們的協同作用及其相互作用。我們身體的11種基本平衡水平中的作用，即膳食平衡、微生物群平衡、腸道通透性平衡、排毒平衡、氧化 – 炎癥平衡、必需脂肪酸平衡、酸堿平衡、神經介質平衡、線粒體平衡、代謝和激素平衡、心理 – 行為平衡。此外，生理營養和功能醫學包含了前沿的學科，比如：荷爾蒙營養。

目標

目標

① 提供真正的臨床生理營養和功能醫學咨詢。
② 采用有科學依據的問卷調查為患者提供營養學、微營養學和內分泌方面的咨詢。
③ 制定個性化營養和微營養管理計劃。

課程

課程

學術論文

1994年10?份, 法國政府?次國家的?型的營養補充調查: “ SU.VI.MAX. ”. 由法國衛?局制定 Serge Hercberg醫?負責。 該研究從1994年開始?直到2003年，歷時8年。總共有13017位男性和?性，?組攝?每?攝?維C、維E、胡蘿卜素、鋅、以及硒。 結論發現： 通過每?攝?抗氧化微量元素，癌癥發病率降低31%，意外傷亡降低37%。

該研究的微量元素定性，定量，以及效果跟蹤是由格勒諾布爾?學?化系負責，安娜瑪麗·羅素教授 也是團隊負責?之?。

安娜瑪麗·羅素教授作為歐洲首批研究生理營養以及微量元素的科學家，從微量元素到細胞能量系列產品的攝取，對婦?，對?年?，對??平運動員，對病理性都有深入研究研究， 并在營養學、臨床醫學、病理學等各領域發表了大量論文。

  1. Stress exposure alters brain mRNA expression of the genes involved in insulin signalling, an effect modified by a high fat/high fructose diet and cinnamon supplement?糖?脂飲?下壓?通過胰島素反應對腦部mRNA(單鏈核糖核酸) 基因表達的改變 POLS ONE – 05/2018
  2. Frederic Canini / Bolin Qin / Anne Marie ROUSSEL 等多位. Positive effects of an oral supplementation by Glisodin, a gliadin-combined SOD rich melon extract, in an animal model of dietary-induced oxidative stress?服Gliosdin (?種法國甜?(Cucumis melo)中提取的超氧化歧化酶 (Superoxide Dismutase; SOD)由??膠原蛋?(Gliadin)的?物?聚物包裹構成）動物實驗上對降低氧化壓?的有效幫助。Nutrition – 02/2015
  3. Isabelle Hininger / M. Osman / Anne-Marie Roussel等多位. Acute stress delays brain mitochondrial permeability transition pore opening Article. 壓?對腦部線粒體的滲透性開?的影響.Journal of neurochemistry – 07/2014
  4. Cecile Batandier / Laurent Poulet / Anne Marie ROUSSEL / 等多位. Trace elements (zinc, selenium, chromium, iron), metabolic syndrome, and type 2 diabetes. 微量元素(鋅，硒，鉻，鐵）在代謝類疾病、?型糖尿病的表達. Médecine des Maladies Métaboliques-01/2014
  5. Anne-Marie Roussel. Cinnamon Counteracts the Negative Effects of a High Fat/High Fructose Diet on Behavior, Brain Insulin Signaling and Alzheimer-Associated Changes. ?桂對?脂肪和?糖餐飲影響，腦部胰島素信號和阿爾茲海默癥的改變. Jounal of POLS online – 12/2013
  6. Richard A Anderson / Bolin Qin /Laurent Poulet / Anne-Marie Roussel等多位. Effects of a high-fat–high-fructose diet, stress and cinnamon on central expression of genes related to immune system, hypothalamic–pituitary–adrenocortical axis function and cerebral plasticity in rats. ?脂?糖飲?，壓?以及?桂對免疫系統基因表達的影響，??鼠腦下丘-腦垂體-腎上腺功能和腦部塑形模型. British Journal of Nutrition – 11/2013
  7. Nathalie Marissal-Arvy / Cecile Batandier / Anne Marie ROUSSEL – 等多位作者. Micronutrient status and cognitive decline in ageing. 微量元素對衰?過程中認知能?下降的影響. European Geriatric Medicine – 02/2011
  8. Monique Ferry / Anne-Marie Roussel.  Chrome et syndrome métabolique: Chromium and the metabolic syndrome. 鉻元素對代謝病理的影響. Médecine des Maladies Métaboliques – 11/2009
  9. Anne-Marie Roussel. Micronutrient status and cognitive decline in ageing. 微量元素對衰?過程中認知能?下降的影響. European Geriatric Medicine – 02/2011
  10. Monique Ferry / Anne-Marie Roussel. Green Tea Extract Decreases Oxidative Stress and Improves Insulin Sensitivity in an Animal Model of Insulin Resistance, the Fructose-Fed Rat. ????脂肪胰島素模型 ：茶葉提取降低氧化危害改善胰島敏感度. Journal of the American College of Nutrition – 08/2009
  11. Isabelle Hininger / Rachida Benaraba / Sara Coves / Anne-Marie Roussel. Antioxidant Effects of a Cinnamon Extract in People with Impaired Fasting Glucose That Are Overweight or Obese ?桂的抗氧化能?在治療超重超胖病?上的?較 Journal of the American College of Nutrition – 03/ 2009
  12. Anne-Marie Roussel / Isabelle Hininger / Rachida Benaraba / Richard A Anderson 等多位. Zinc supplementation does not alter plasma homocysteine, vitamin B12 and red blood cell folate concentrations in French elderly subjects. 法國?年?群鋅攝?對?漿中同型半胱氨酸，維?素B12以及紅細胞中天然葉酸的影響. Journal of Trace Elements in Medicine and Biology – 01/ 2009
  13. Véronique Ducros / Maud Andriollo / Josiane Arnaud/ Anne-Marie Roussel.  Fibrates but not statins increase plasma selenium in dyslipidemic aged patients – The EVA study ?丁酸類降脂藥(Fibrate) ，?他汀類藥物增加?脂異常?年?的?漿中的硒含量. （EVA-Etude du viellissment Arteriel ） – 01/2009
  14. Josiane Arnaud / Tasnime Akbaraly / Isabelle Hininger / Anne-Marie Roussel. Relationships between selenium, lipids, iron status and hormonal therapy in women of the SU.VIMAX cohort. 硒元素，脂肪，鐵元素和?性荷爾蒙治療的關系. Journal of Trace Elements in Medicine and Biology 12/ 2007
  15. Josiane Arnaud / Anne-Marie Roussel/ Serge Hercberg 等多位. Effect of Low Dose Antioxidant Vitamin and Trace Element Supplementation on the Urinary Concentrations of Thromboxane and Prostacyclin Metabolites. 低劑量抗氧化劑和微量元素補充在尿液中前列環素和?栓素B2的變化. Journal of American College Nutrition – 11/2007
  16. Josiane Arnaud / Muriel Bost Anne Marie ROUSSEL / 等多位. Micronutrients and cognitive impairment. 微量元素和認知功能損傷的聯系. Revue de Geriatrie – 04/2007
  17. Monique Ferry / Anne-Marie Roussel.  Mitochondrial production of reactive oxygen species and incidence of ageassociated lymphoma in OF1 mice: Effect of alternate-day fasting. 線粒體能量產?和??淋巴瘤在階段型斷?的研究. Mechanisms of Ageing and Development – 12/2005
  18. Anne-Marie Roussel / Olivier Descamps / Jacqueline Riondel / Véronique Ducros. Alterations of antioxidant trace elements (Zn, Se, Cu) and related metallo-enzymes in plasma and tissues following burn injury in rats. ?不同抗氧化元素和相關酶制劑對燒傷??組織的研究. BURNS – 06/2005
  19. D Agay / R.A. Anderson / C Sandre / Yves Chancerelle / Anne-Marie ROUSSEL. Influence of Short-Chain Fructo-Oligosaccharides (sc-FOS) on Absorption of Cu, Zn, and Se in Healthy Postmenopausal Women. 短鏈低聚果糖對絕經期女性鈣、鋅和硒元素吸收的影響. Journal of the American College of Nutrition – 03/2005
  20. Véronique Ducros / Anne-Marie Roussel 等多位. Antioxidant vitamin status in high exposure to oxidative stress in competitive athletes. ??平運動員的抗氧化元素狀態研究. BRITISH JOURNAL OF NUTRITION -09/2004
  21. Anne Marie Roussel / Anne-Sophie Rousseau 等多位. Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: A randomized double-blind, placebocontrolled trial in apparently healthy pregnant women. 微量元素攝?對孕婦和新??的?化變化的影響：一項對健康的孕婦中進行的隨機雙盲安慰劑對照試驗. European Journal of Clinical Nutrition – 02/2004
  22. Anne-Marie Roussel / Isabelle Hininger /等多位. No Antioxidant Effect of Combined HRT on LDL Oxidizability and Oxidative Stress Biomarkers in Treated Post-Menopausal Women. 絕經期?性對氧化和抗氧化治療的?化反應.Journal of the American College of Nutrition – 08/2002
  23. Anne-Marie Roussel / Isabelle Bureau / 等多位. Beneficial effect of an antioxidant micronutrient-enriched food on DNA damage: experimental study in rats using a modified comet assay in total blood. 抗氧化微量元素?物對DNA（基因）受損的研究 （???液研究試驗）. IARC Scientific publication – 02/2002
  24. Anne-Marie Roussel / Isabelle Hininger / 等多位. Trace mineral status in post menopausal women: Impact of hormonal replacement therapy. 絕經期婦?荷爾蒙治療微量元素跟蹤. Journal of Trace Elements in Medicine and Biology – 02/2002
  25. Anne-Marie Roussel / Isabelle Bureau / Richard A 等多位. Determinants of Blood Selenium Concentrations in France (SU.VI MAX Study). 法國人?液中硒元素含量.Trace Elements in Man and Animals – 01/2002
  26. Arnaud / Anne-Marie Roussel / Paul Preziosi 等多位. Oxidative Stress and Antioxidant Trace Element Status in Patients with Non-insulinDependent Diabetes. 氧化問題以及抗氧化狀態在?胰島素糖尿病 – 01/2002
  27. A.Kerkeni / Anne-Marie Roussel / Ali Othmane/ 等多位. Potential Antioxidant Effects of Zinc and Chromium Supplementation in People with Type 2 Diabetes Mellitus. 鋅和鉻補充劑對2型糖尿病患者的潛在抗氧化作用. Journal of the American College of Nutrition – 07/2001
  28. Richard A. Anderson / Anne-Marie Roussel / Nouri Zouari[…] / Abdelhamid Kerkeni. The SU.VI.MAX Study”: a primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers. Supplementation on VItamines et Minéraux Antioxydants. 法國國家SU.VI.MAX研究：抗氧化、維生素、微量元素在??管和癌癥預防??的應?.  Food and Chemical Toxicology – 09/1999
  29. Serge Hercberg / Paul Preziosi / Anne-Marie Roussel /等多位. Systemic Oxidative Stress and Cognitive Performance in the Population-Based EVA Study. 氧化衰?和認知系統在衰?的應?. Free Radical Biology and Medicine – 05/1998
  30. J Richard / Anne-Marie Roussel / C Bonithon-Kopp. Analyzed dietary intakes, plasma concentrations of zinc, copper, and selenium, and related antioxidant enzyme activities in hospitalized elderly women.住院年輕女性?漿中鋅、銅、硒、其他微量元素，抗氧化含量和?物攝取之間的聯系. Journal of the American College of Nutrition – 11/1996
  31. A Schmuck / Anne Marie ROUSSEL / J Arnaud / Ducros. Vitamin Intakes (A, E, C, Carotenes) In A French Institution: Assessment By The Duplicate-Diet Method. 法國人的維生素攝入量（A，E，C，胡蘿卜素）：采用重復飲食法進行評估. Annals of Nutrition and Metabolism – 02/1995
  32. A Poupard / Anne-Marie Roussel / J Alary. Effect of acute zinc deficiency on insulin receptor binding in rat adipocytes. 鋅缺乏對于??脂肪細胞中胰島素的影響. Biological Trace Element Research – 05/1992
  33. Marie-Jeanne Gomot / Patrice Faure/ Anne-Marie Roussel/等多位. Effects of varying dietary proteins on plasma lipids and rabbit platelet function.不?飲?和蛋?質攝取對?液脂肪和兔??板活化因?的影響. Thrombosis Research- 03/1988
  34. A Ravel / Anne-Marie Roussel / J Alary / J Laturaze. Nutritional value: Experimental analysis of effect on fat metabolism in rats.分析營養對???的代謝的影響.Jan 1980
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